![]() The use of PRNT to infer the serotype of infection for secondary infections or heterotypic antibody responses is generally discouraged. Previous experimental studies demonstrated that in case of primary DENV infections, the highest late convalescent PRNT values are against the infecting serotype. So far, no universal definitions have been developed for the interpretation of PRNT 50 data for this purpose. Despite this cross-reactivity of DENV antibodies, PRNT 50 has been used to make inference on the serotype of DENV infections. In response to a DENV infection, cross-reactive antibodies are produced against epitopes of DENV proteins that are identical across serotypes, allowing these antibodies to react to and perhaps neutralize more than one serotype. This test was originally developed in the late 1960’s by Russell and Nisalak and later adapted to quantify serotype-specific antibody titers using probit analysis. Ĭurrently, the measurement of plaque reduction neutralization titers (PRNT) is the most widely used test for determining serotype-specific antibodies against DENV. Several dengue vaccine candidates are in an advanced stage of development and phase 3 trials are about to start in endemic countries. With no curative treatment and the difficulty of sustaining vector control programs, most hope for dengue control is based on the development of a safe and effective vaccine. DENV has four serotypes (DENV-1, 2, 3 and 4) that cause an estimated 34 million reported illnesses and over 20,000 deaths per year. O23 - Service: CyberLink Background Capture Service (CBCS) (CLCapSvc) - Unknown owner - C:\Program Files\HP\QuickPlay\Kernel\TV\CLCapSvc.Dengue virus (DENV) is one of the most important emerging viruses worldwide. ![]() O23 - Service: AVG7 Resident Shield Service (AvgCoreSvc) - GRISOFT, s.r.o. ![]() O23 - Service: AVG7 Update Service (Avg7UpdSvc) - GRISOFT, s.r.o. O23 - Service: AVG7 Alert Manager Server (Avg7Alrt) - GRISOFT, s.r.o. O3 - Toolbar: &Google - (Performance Viewer Activex Control). R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName = R0 - HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch = R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant = R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = C:\Program Files\Intel\Intel Matrix Storage Manager\IAAnotif.exeĬ:\Program Files\HP\QuickPlay\QPService.exeĬ:\Program Files\Hewlett-Packard\HP Quick Launch Buttons\QLBCTRL.exeĬ:\Program Files\Hewlett-Packard\HP Wireless Assistant\HPWAMain.exeĬ:\Program Files\Hewlett-Packard\HP Wireless Assistant\WiFiMsg.exeĬ:\Program Files\HP\HP Software Update\hpwuSchd2.exeĬ:\Program Files\Java\jre1.6.0_05\bin\jusched.exeĬ:\Program Files\Omni\OmniMouse Driver\3.82\Mouse32A.exeĬ:\Program Files\Windows Live\Messenger\msnmsgr.exeĬ:\Program Files\Google\GoogleToolbarNotifier\.5462\GoogleToolbarNotifier.exeĬ:\Program Files\Windows Media Player\wmpnscfg.exeĬ:\Program Files\Hewlett-Packard\Shared\HpqToaster.exeĬ:\Program Files\Common Files\Microsoft Shared\Windows Live\WLLoginProxy.exeĬ:\Program Files\Adobe\Reader 8.0\Reader\AcroRd32.exeĬ:\Program Files\BitTorrent\bittorrent.exeĬ:\Program Files\Internet Explorer\iexplore.exeĬ:\Program Files\Mozilla Firefox\firefox.exeĬ:\Program Files\Trend Micro\HijackThis\HijackThis.exe
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